John Shriver , Nov 15, 2013; 07:12 a.m.
You can develop one roll at a time, and still use those compensations for the developer wearing out.
Your real challenge is using all 16 rolls worth in the limited lifetime of the kit.
A powder kit must always be mixed entirely at once.
If it's the liquid kit, you still have the problem that one part of the developer is probably back-filled with nitrogen gas at the factory, and once you open that bottle and let oxygen in, you've set off the "time bomb". C-41 developer is very sensitive to oxygen.